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Are Total Serum IgE Levels Good Predictors Of Allergies In Children?
Sunday, March 2, 2014
Exhibit Hall B (Convention Center)
Stephanie Barnes-Mercado, Vylma Velazquez, MD, Annette Pietri-Ramirez
Rationale : Atopy is a tendency to produce IgE antibodies in response to low doses of allergens. A considerable number of atopic patients have elevated serum IgE levels. We sought to evaluate the association between different allergic diseases and the serum IgE levels of atopic patients.

Objectives: To study the role of total Serum IgE levels as a marker of allergy and its association with different systemic allergies.

Methods: A cross sectional comparative study conducted at an outpatient clinic for allergy and immunology services in Ponce, Puerto Rico, revision over the period of 5 years (2008-2012). 100 children in the age group 6 months to 18 years meeting the inclusion criteria (atopic and Serum IgE available) were enrolled in the study. Variables included demographic, allergy evaluation and total IgE, and statistics analyses.

Results: Serum IgE levels ranged from 3.7 IU/mL to 15,511.2 IU/mL, mean value of the sample of 1,007.7 IU/mL. 59 patients presented increased serum IgE levels. The largest group in our sample were the allergic rhinitis patients (n=43) with IgE levels mean 672.3 IU/mL. Patients with atopic dermatitis, asthma and angiodema presented the highest mean IgE levels with 2,564.8 IU/mL, 2,249 IU/mL and 2,437 IU/mL respectively. The conditions with the most patients with high IgE levels were allergic rhinitis, urticaria and asthma with over 60% of each group exhibiting increased levels of IgE.

Conclusions: Atopic patients may present with high serum IgE levels, which varied among the atopic conditions. Asthmatic patients had the highest prevalence of increased serum levels of IgE.