Objectives: To study the role of total Serum IgE levels as a marker of allergy and its association with different systemic allergies.
Methods: A cross sectional comparative study conducted at an outpatient clinic for allergy and immunology services in Ponce, Puerto Rico, revision over the period of 5 years (2008-2012). 100 children in the age group 6 months to 18 years meeting the inclusion criteria (atopic and Serum IgE available) were enrolled in the study. Variables included demographic, allergy evaluation and total IgE, and statistics analyses.
Results: Serum IgE levels ranged from 3.7 IU/mL to 15,511.2 IU/mL, mean value of the sample of 1,007.7 IU/mL. 59 patients presented increased serum IgE levels. The largest group in our sample were the allergic rhinitis patients (n=43) with IgE levels mean 672.3 IU/mL. Patients with atopic dermatitis, asthma and angiodema presented the highest mean IgE levels with 2,564.8 IU/mL, 2,249 IU/mL and 2,437 IU/mL respectively. The conditions with the most patients with high IgE levels were allergic rhinitis, urticaria and asthma with over 60% of each group exhibiting increased levels of IgE.
Conclusions: Atopic patients may present with high serum IgE levels, which varied among the atopic conditions. Asthmatic patients had the highest prevalence of increased serum levels of IgE.