Anthropomorphic Variations According To Clinical Pattern In Cow's Milk Allergic Children
Saturday, March 1, 2014
Exhibit Hall B (Convention Center)
Diana Colson, Nicolas Kalach, MD, Ph D, Pascale Soulaines, Christophe Dupont, MD PhD
Rationale: to investigate the long-term effects of feeding with amino-acid (AAF) or extensive whey hydrolysate-based formula (eWHF) on growth, clinical and allergic parameters in mono- and poly-allergic children.

Methods: a telephone survey analyzed retrospectively 515 consecutive (2004-2010) children with digestive/cutaneous/respiratory symptoms related to mono-allergy (cow’s milk protein) or poly-allergy (≥2 foods) in a food allergy reference center (Arsène Cohort, n°DC-2009-955). Children were enrolled if having been fed for ≥6mo with ≥500mL/day of AAF (Neocate®/Neocate Advance®) or of eWHF (Pepti-Junior®), in combination with an adapted elimination diet. Parental questionnaires provided information on height, weight, evolution of clinical manifestations and allergens sensitization. Analyses retained 135 children, for whom information was available at age 5.9±2.75 years (mean±SD).

Results: at survey, BMI (z-scores) in mono-allergic children was significantly higher than in poly-allergic children, p 0.04. BMI of mono-allergic males fed with AAF tended to be higher than in poly-allergic p 0.09. BMI of poly-allergic males fed with AAF tended to be lower than in those fed with eWHF, p 0.057. BMI in children with respiratory sensitization and asthma was significantly higher than in those without respiratory sensitization and asthma, p 0.05. In children fed with AAF, the percentage of persistent respiratory symptoms was 2.0%, i.e. 6 times smaller than after eWHF feeding 12.1%, p 0.032.

Conclusions: in mono-allergic children BMI is higher than in poly-allergic. Children with respiratory sensitization and asthma have higher BMI than ones with cutaneuos/digestive symptoms. The replacement formula used, AAF vs eWHF, might exert some influence.