Allergic Rhinitis, Asthma and Cardiovascular Disease
Monday, March 3, 2014: 2:30 PM
Room 7AB (Convention Center)
Angelina M. Crans Yoon, MD, , , ,
Rationale: Several studies have suggested an association between eosinophilia, positive skin tests, total IgE, daily pollen burden, asthma and cardiovascular disease. The relationship between cardiovascular disease and allergic rhinitis is largely unknown.

Methods: We assembled a cohort of allergic rhinitis patients (N=109,229) and a cohort of asthma patients (N=92,775) matched 1:1 by age, sex, and ethnicity to reference cohorts and compared the incidence of cardiovascular and cerebrovascular events and all-cause mortality from 1/1/1995 to 12/31/2012 using the Kaiser Permanente Southern California regional database and ICD-9 codes. Hazard ratios (HR) were calculated using survival analysis with a fully adjusted COX proportional model.

Results: Patients with allergic rhinitis had significantly lower risk for acute myocardial infarction (MI) (HR 0.75, 95% CI [0.71, 0.80]) and cerebrovascular disease (HR 0.81, 95% CI [0.77, 0.84]), and all-cause mortality (HR 0.51, 95% CI [0.49, 0.53]). However, their risk of all cardiovascular events was equivalent to the control cohort (HR 0.97, 95% CI [0.94, 1.00]). Patients with asthma had significantly higher risk of all cardiovascular disease (HR 1.36, 95% CI [1.32, 1.40]), however had no significantly increased risk of cerebrovascular disease (HR 1.03, 95% CI [0.99, 1.08]) or all-cause mortality (HR 1.00, 95% CI [0.97, 1.03]).

Conclusions: Our study supported other results that patients with asthma have increased cardiovascular events. However patients with allergic rhinitis have decreased acute MI, cerebrovascular disease, and all-cause mortality. This suggests atopy may not be contributing to the increased cardiovascular events seen in patients with asthma.