Methods: Case 1: A 31-year old female had been diagnosed with CCS by a stomatologist due to symptomatic episodes of pain, burning and redness of the tongue and the buccal mucosa at the occlusal level following use of cinnamon-flavored chewing gums. Case 2: A 39-year old female had been initially diagnosed with herpetic gingivostomatitis, due to the presence of widespread erosive lesions on the gingiva and buccal mucosa at initial intraoral examination, but this diagnosis was changed to probable CCS after negative cultures and serologic testing for HSV as well as recurrence of lesions upon rechallenge with cinnamon.
Results: Case 1: Patch tests for fragrance mix (including cinnamic alcohol and cinnamic aldeyde) were performed with positive results, while patch testing for cinnamon powder was negative. The patient was advised to avoid use of cinnamon-flavored chewing gums, with no recurrence of symptoms during a follow up period of 5 months. Case 2: Patch tests for fragrance mix were performed with negative results, while patch testing for cinnamon powder was positive. The patient was advised to avoid consumption of cinnamon powder and had no recurrence of stomatitis during a 4 month follow up period.
Conclusions: Cinnamon contact stomatitis is a rare condition needing proper evaluation from a stomatologist as well as an allergologist in order to set the correct diagnosis.