Effectiveness of Premedication and Rapid Desensitization in Hypersensitivity to L-Asparaginase
Saturday, March 5, 2016
South Exhibit Hall H (Convention Center)
Jin-Tack Kim, MD. PhD, Hwan Soo Kim, MD, Yoon Hong Chun, MD, Jong-seo Yoon, MD, PhD, Hyun Hee Kim, MD

L-asparaginase is a crucial chemotherapeutic agent for the treatment of acute lymphoblastic leukemia. However, hypersensitivity to L-asparaginase is common which limits its usage.


We performed 44 cases premedication and 3 cases of desensitization in 16 patients with hypersensitivity to L-asparaginase.


With premedication, 33 cases completed L-asparaginase injection with no hypersensitivity reaction. 11 cases showed mild hypersensitivity reaction, such as urticaria. Desensitization was performed in 3 cases: 2 cases were successful and in 1 case, medication was switched to Erwiniaasparaginase.


Premedication and desensitization appears to be useful in helping patients receive desired dose of L-asparaginase in pediatric patients with acute lymphoblastic leukemia.