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Surgical Therapy Reduces Blood Eosinophil Counts in Eosinophilic Chronic Rhinosinusitis
Saturday, March 5, 2016
South Exhibit Hall H (Convention Center)
Dai Takagi, Yuji Nakamaru, Satoshi Fukuda
Rationale:

It has been reported that eosinophilic chronic rhinosinusitis (ECRS) coexists at high levels with asthma, and frequently recurs after surgery. An elevated peripheral eosinophil count is an important factor in predicting the recurrence of ECRS. In this study, we investigated postoperative changes in blood eosinophil count and other biomarkers in ECRS patients.  

Methods:

Twenty-two patients with ECRS who were treated with endoscopic sinus surgery (ESS) were examined for blood eosinophil count, total serum IgE and serum IL-5 before and after surgery. Data were compared with those for non-ECRS patients and patients with chronic rhinosinusitis without polyps. We also analyzed the differences between good-controlled ECRS patients and patients who experienced recurrence.

Results: The blood eosinophil count was significantly decreased after surgery in the ECRS group, but not in the non-ECRS group. Serum IL-5 also tended to be reduced after surgery in ECRS patients. An analysis of the ratio of serum IL-5 (pre-ESS/post-ESS) in patients showed that it was significantly higher in the ECRS group than in the CRSsNP group. Among ECRS patients, the preoperative blood eosinophil count was significantly higher in RG patients. Furthermore, in the RG group, the blood eosinophil count was significantly decreased after endoscopic sinus surgery compared with the good-controlled group.

Conclusions:

The blood eosinophil count was reduced after ESS in the ECRS patients. Postoperative changes in eosinophil count might be used to predict the prognosis for ECRS patients. The blood eosinophil count in ECRS may reflect local and systemic factors in its pathogenesis.