Comparison of the Effect of Aspirin and Heparin with or without Intravenous Immunoglobulin in Treatment of Recurrent Abortion with Unknown Etiology: A Clinical Study
Monday, March 7, 2016
South Exhibit Hall H (Convention Center)
Zeinab Nazari, Javad Ghaffari, Aghdas Ebadi
Rationale: Abortion is the most common complication of pregnancy, defi ned as spontaneous expulsion of
products of conception before 24 weeks of pregnancy or termination of pregnancy with a fetus weighing <500 g. The aim of this study
was to compare the effi cacy of intravenous immunoglobulin (IVIG) in combination regimens with aspirin and heparin versus aspirin
and heparin combination alone in women with idiopathic recurrent abortion.

Methods: This randomized, clinical trial was performed at Imam Khomeini Hospital in Sari-Iran between March 2010 and March 2013. Sixty people were randomly
allocated into two groups. The control group was treated by subcutaneous enoxaparin 40 mg daily up to 24 weeks associated
with aspirin 80 mg daily up to 37 weeks of gestation. The intervention group received IVIG 200 mg/kg monthly up to 24 weeks of
gestation with enoxaparin and aspirin for the same therapeutic period and the same dose as the control group.

Results: Three patients (10%) in the intervention group had abortion and 25 (90%) had live births with mean birth weight 3.5 ± 0.9 kg. Four patients
(13%) in the control group had abortions, and 28 (87%) had live births with birth weight 3.4 ± 1.2 kg (P = 0.74). The difference
was not statistically signifi cant.

Conclusions: It seems that employing the heparin and aspirin combination therapeutic regimen
is appropriate for idiopathic abortions and avoids the high cost of IVIG use and its complications.