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Descriptive Analysis of Patients with Allergic Reactions to Fluoroquinolones
Saturday, March 5, 2016
South Exhibit Hall H (Convention Center)
Esther Barrionuevo, MD, PhD, Inmaculada Doña, MD, PhD, Francisca Gómez, MD, PhD, Oliver Muñoz-Daga, Arturo Ruiz, MD, Antonio Guzman, Maria Auxiliadora Guerrero, Maria Dolores Ruiz, Rosa Garcia, Miguel Blanca, MD, PhD, María José Torres, MD, PhD
Rationale:  Fluoroquinolones (FQ) are the second most frequent cause of hypersensitivity to antibiotics after betalactams. In recent years, an increase in the number of patients allergic to these drugs has been detected. The aim of our study was to describe the clinical characteristics and the methods used for diagnosing patients with allergy to FQ. 

Methods: Patients attending our allergy unit with reactions suggestive of allergy to FQ were evaluated in 2005-2014. Diagnosis was achieved by clinical history, basophil activation test (BAT) and drug provocation test (DPT) when necessary. 

Results: A total of 365 patients with suggestive allergic reaction to FQ were evaluated, of which 140 were confirmed as allergic (38,35%). Just over two thirds (69,28%) were female, and the mean age was 54.75±19,36 (18-80) years. Sixty five per cent reacted less than 1h after drug administration and 35% more than 1h later. Moxifloxacin was the FQ involved in 60.86% of cases, Ciprofloxacin in 20.28%, Levofloxacin in 13% Norfloxacin in 4.34% Ofloxacin in 1.44%. The most frequent clinical entity was anaphylaxis (55.71%) followed by generalized urticaria (33.57%), exanthema (7.14%) and angioedema (3.57%). In patients with immediate reactions, the diagnosis was achieved using BAT in 64.70%, by clinical history in 29.41% and by DPT in 5.88%. In patients with non-immediate reactions, diagnosis was performed by clinical history in 55.55%, by DPT in 33.33% and by TAB in 11.11%.

Conclusions: Most reactions induced by FQ were immediate (anaphylaxis), being Moxifloxacin the drug most frequently involved. The BAT seems to be a useful method for diagnosing these patients.