Treatment of Percistent Blepharitis and Keratoconjuctivitis with Intraocular and Topical Use of Tacrolimus 0.03% Ointment.
Monday, March 7, 2016
South Exhibit Hall H (Convention Center)
Konstantinos Syrigos, Nikolaos K Syrigos, Maria Vasiliou, Maria Zande, Ekaterini I. Syrigou, PhD

To report a case of persistent blepharitis and keratoconjunctivitis despite the oral use of corticosteroids treated at last with topical and intraocular use of tacrolimus 0.03% ointment.


A male patient, aged 42, presented with persistent blepharitis and limbic keratoconjuctivitis in both eyes. The patient had previously received several treatments (such as topical: steroids and cyclosporine and per os: methylprednisolone, median dose: 32mg, for one year), with no improvement. Clinically he showed blepharitis with burning, itching, abnormally greasy tearing and severe keratoconjunctivitis (tingling, itching, pain in some cases, thick mucous secretions and atopic dermatitis on the eyelids).Because of poor response to initial management, we started treatment with intraocular and topical use of tacrolimus 0.03% twice a day.


A week later, the patient appeared with significant clinical improvement.

Four weeks later they were no signs of blepharitis and keratoconjuctivitis. Tacrolimus was successfully tapered. There were no side effects.


Intraocular and topical use of tacrolimus 0.03% ointment may be considered an additional treatment option for keratoconjunctivitis.