Risk Factors for Severe Eczema in Children: Findings from a National Web-Based Survey
Sunday, March 6, 2016
South Exhibit Hall H (Convention Center)
Mari Sasaki, MD, Koichi Yoshida, MD, Yuichi Adachi, MD, PhD, Mayumi Furukawa, MD, Toshiko Itazawa, MD, PhD, Hiroshi Odajima, MD, PhD, Hirohisa Saito, MD, PhD, Akira Akasawa, MD, PhD
Rationale: Genetic and environmental factors are known to be related to the development of atopic eczema. However, the predictors of eczema severity are not fully understood. Our aim was to assess factors associated with the severity of eczema among pediatric patients in the general population.

Methods: In June 2012, we conducted a nation-wide web-based survey to identify the prevalence and characteristics of allergic diseases in Japanese children. The prevalence and severity of eczema was assessed using the ISAAC (International Study of Asthma and Allergies in Childhood) core questionnaire. Associations between eczema severity with environmental factors, demographics and comorbid allergic diseases were evaluated among 6-12 year old children.

Results: A total of 28,348 children aged 6-12 were included in the analysis. The prevalence of current eczema was 13.0%, 15.6% among them had severe disease. Multivariate regression analysis showed that paternal eczema and having 3 or more children in the household were risk factors of severe eczema {adjusted OR [95%CI]: 1.44[1.10-1.87] and 1.43[1.07-1.91], respectively}. The risk of severe eczema was increased in those with an onset before age 2 compared with those who developed eczema after age 5 {adjusted OR [95%CI]: 1.48[1.16-1.88]}. There was a U-shaped relation between the prevalence of severe disease and annual household income, with the difference still significant between the low and middle income group in the multivariate analysis model.


A nation-wide web survey showed that along with family history and disease duration, other environmental factors such as the number of children and household income influence disease severity in childhood eczema.