No Association Between Atopic Outcomes and Pertussis Vaccine Given in Children Born on the Isle of Wight 2001-2
Saturday, March 5, 2016
South Exhibit Hall H (Convention Center)
Carina Venter, PhD RD, Julia Stowe, BA (Hons), Nick Andrews, PhD, Elizabeth Miller, FRCPath, Paul J. Turner, FRACP PhD

Rationale: Public health bodies in the USA, Australia and Europe have noted that there has been an increase in food allergy which coincides with the switch from whole cell (WCP) to acellular pertussis (AcP) vaccination in the US, Australia and Europe. AcP drives a Th2-like immune response, in contrast to the WCP vaccine.

Methods: The transition from WCP to AcP vaccine in the UK coincided with the establishment of a large birth cohort study on the Isle of Wight in 2001/2002 to assess atopic/allergic outcomes through to age 10 years. We analysed outcome data and linked this with the type of pertussis vaccine given to compare rates according to the number of doses of AcP received. Outcomes assessed included: IgE-mediated food allergy, asthma at 3 and 10 years, eczema at 6 months/1 year/3 years, allergic rhinitis and atopy (positive SPT).

Results: A total of 701 children were included in the primary analysis which was all those who received a first infant dose before 18 weeks of age, and doses 2 and 3 (if given) under 12 months of age. No significant association between any outcome measure and type of pertussis vaccine were identified. Of those who had had at least one AcP dose 10/340 (2.9%) had IgE-mediated food allergy compared to 8/356 (2.2%) of those with no AcP doses (P=0.64).

Conclusions: We did not identify any link between type of pertussis vaccine received in infancy and allergic/atopic outcomes.