Methods: 354 children (6-8 years) with atopy were included from prospective CHEER study. Atopy was defined by positive responses to more than 1allergens on SPTs. Latent Class Analysis (LCA) was used for cluster analysis.
Results: Four phenotypes were characterized as "indoor allergen dominant with low IgE" (14%, cluster 1), "multiple sensitization" (13%, cluster 2), "outdoor allergen dominant with late indoor allergen sensitization" (10%, cluster 3), and “indoor allergen dominant" (63%, cluster 4). The prevalence of allergic rhinitis (AR) and bronchial hyperresponsiveness (BHR) were relatively higher in cluster 2 and 4, whereas only cluster 2 associated with new cases of AR during 4 year follow-up (aOR 5.7; 95% CI 1.6–20.5). Cluster 3 associated with the highest prevalence of new cases of asthma during the follow-up (aOR 5.1, 95% CI 1.3–20.7).
Conclusions: Children with multiple indoor and outdoor allergens sensitization and outdoor allergens sensitization with later sensitization to indoor allergens might be associated with the new development of AR or asthma.
Funding sources: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and future Planning (NRF-2014R1A2A1A10050687).