Prevalence of Respiratory Viruses in Patients with Acute Respiratory Infections in Korea
Saturday, March 5, 2016
South Exhibit Hall H (Convention Center)
Jin-sung Park, Hee-Dong Jung, Hyang-Min Jung, Sung-Soon Kim, Chang-Keun Kim, MD FAAAAI

Acute Respiratory Infections (ARI) are the most common infectious disease that caused significant morbidity and mortality with consequently an enormous economic burden. Since Dec 2005, Korea Centers for Disease Control and Prevention has been running surveillance system KINRESS(Korea Influenza and Respiratory Virus Surveillance System) for the detection of major respiratory viruses. We investigated the viral pathogen causing ARI in Korea, 2013.


We performed multiplex PCR/RT-PCR on respiratory specimen(throat oral nasal swab) to determine the prevalence of 14 viruses including adenovirus(HAdV), parainfluenza virus(HPIV) 1, 2, 3, respiratory syncytial virus(HRSV) A and B, influenza virus(IFV) H1N1pdm09, H3N2, B, human coronavirus(HCoV) 229E, NL63 and OC43, human rhinovirus (HRV), human bocavirus(HBoV) and human metapneumovirus(HMPV). And the statistical analysis was performed to investigate the characteristics of age-distribution, seasonality, and clinical features of ARI patients.


Respiratory viruses were detected by 49.4% of enrolled patients(n=15,050), and 1-5 year-old age group accounted for almost. However, significant differences were not observed depending on the age group of virus detection rate. HAdV, HPIV, HRSV, HCoV, HBoV and HMPV were mainly detected from under 5 years old. IFV were mainly detected on over 6 years old. HRSV, IFV, HCoV infections were peaked in winter season. In summer, incidence of HPIV and HBoV were increased. When we analyzed the association of viral infection with clinical feature, almost infections were correlated with fever, cough and runny nose.


Our data suggest that there was a meaningful relationship between viral infection and typical manifestation of known clinical feature as well as seasonality and age distribution.