875
The Sensitization Model and Correlation of Bermuda Grass and Timothy Grass Pollen Allergen in Respiratory Allergic Diseases Patients in Southern China
Monday, March 7, 2016
South Exhibit Hall H (Convention Center)
Luo Wenting, Baoqing Sun
Rationale: Study on the sensitization model and correlation of bermuda and timothy grass allergen in allergic patients in Southern China.

Methods: 258 cases of patients with allergic diseases, including 92 asthma patients, 78 allergic rhinitis patients, 88 rhinitis with asthma. Serum sIgE of bermuda, timothy and Japanese hop were detected by UnitCAP. If the bermuda-sIgE were positive, sIgE of Cyn d1, Phl p1, Phl p4, peanut, Ara h1, Ara h8, birch, Bet v1 and CCD were tested.

Results: The sensitization rate of bermuda, timothy and Japanese hop in 258 patients were 22.5%, 13.6% and 9.3% respectively. 53.4%(31/58) bermuda sIgE-positive patients were sensitized to Cyn d1. 100%(35/35) timothy-positive patients were sensitized to Phl p4, but only 17.1%(6/35) were positive to Phl p1. 41.4% of Bermuda-sIgE-positive patients were Japanese hop sIgE-positive. 56.9%(33/58) bermuda-positive patients were sensitized to peanut. Ara h1 were positive in 3 patients. 32.8%(19/18) were sensitized to birch. 6 patients were sensitized to Bet v4 and Ara h8 simultaneously. 39.7%(23/58) bermuda-positive patients with CCD sensitization, and CCD sIgE levels correlated well with bermuda, Cyn d1, timothy and Phl p 4, peanut, birch(P<0.01).

Conclusions: The sensitization rate of bermuda, timothy and Japanese hop were 22.5%, 13.6% and 9.3% in Southern China. Bermuda sIgE-positive patients were sensitized to timothy, peanuts, CCD and birch and Japanese hop in different degree. Phl p4 was the main component of timothy. CCD had good correlations with grass pollen, peanut and birch allergens, indicated wide cross-reactions between them were caused by carbohydrate cross-react determinants.