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Association Between Asthma Control Test, Peripheral Eosinophil Counts, and Serum Total Immunoglobulin E Levels in Severe Asthmatics
Monday, March 7, 2016
South Exhibit Hall H (Convention Center)
Santiago Alvarez Arango, MD, Jennifer Toh, MD, Denisa Ferastraoaru, MD MSc, Gabriele de Vos, M.D., M.Sc., David L. Rosenstreich, MD FAAAAI, Sunit P. Jariwala, MD
Rationale: There is a lack of published data surrounding the association between asthma control test (ACT) scores, absolute eosinophil counts, and serum total immunoglobulin E (IgE). This study aims to evaluate this association to better understand asthma phenotypes.   

Methods: The charts of 63 severe asthma patients at Montefiore’s Asthma Center (MAC) in the Bronx, NY were reviewed. Patient criteria included at least one asthma-related emergency department visit or asthma-related hospitalization within the last 12 months. The baseline ACT score, absolute eosinophil counts, and serum total IgE were analyzed and correlations were determined using the Spearman rank test. Patients using systemic corticosteroids in the 4 weeks prior to the ACT score collection were excluded.  

Results: Among the 63 patients, 17% were male, with a mean age of 50 years (SD = 15). Most of these patients were minorities (41% Hispanic, and 46% African-American). The median for ACT score was 10 (5 – 23), absolute eosinophil count was 200 (0 – 1700 cells/uL), and serum total IgE was 302 (9.7 – 4620 IU/mL). The mean time interval between the evaluation of ACT scores and blood collection was 10 days (SD = 15). ACT scores negatively correlated with absolute eosinophil counts (rho= -0.316, p = 0.012). There was no significant correlation between ACT scores and serum total IgE (rho = 0.065, p = 0.614).  

Conclusions: Absolute eosinophil counts significantly and negatively correlated with ACT scores among MAC patients. Additional studies are needed to determine if this correlation might help to phenotype and further assess severe asthma patients.