Association of Aspergillus Monosensitization with Asthma and Rhinosinusitis
Saturday, March 5, 2016
South Exhibit Hall H (Convention Center)
Julie T. Abraham, MD, Maria A. Barcena Blanch, MD, Roxana I. Siles, MD
Rationale: Aspergillus fumigatus is a ubiquitous mold linked to respiratory disease. Previous studies demonstrate conflicting results regarding asthma and rhinitis in patients sensitized to molds. We aim to identify the association of aspergillus monosensitization with severity and control of asthma and rhinosinusitis.

Methods: We performed a retrospective chart review of patients who underwent skin testing from 2012 to 2015. We included patients with negative skin prick tests who underwent intradermal skin testing (IDST).

Results: Out of 1467 randomly selected cases, 215 (154 females and 61 males) met inclusion criteria and were grouped based on IDST: 1) negative IDST (n=93); 2) positive aspergillus only (n=34); 3) other positive inhalants (n=88). Mean age was 52.0±15.7 years. Overall asthma rate was 38.1% (29%, 56% and 41% respectively; p<0.05), with no significant difference in asthma severity between groups (p=0.44). 79% of patients in group 2 reported asthma control, compared to <50% in other groups (p=0.06). Overall rhinosinusitis rate was 97.2% (98%, 94% and 98% respectively; p=0.46). 50% of patients in group 2 reported control of rhinosinusitis, compared to 20% in other groups (p<0.05). There was no statistical difference in rhinosinusitis control among patients in groups 1 and 3 (p=0.97).

Conclusions: Monosensitization to Aspergillus was associated with higher asthma rate, but not with increased asthma severity or control.   Monosensitization to Aspergillus did not differ in the rate of rhinosinusitis, but was associated with better control compared to the other groups.