Methods: Seventy four Children with AIU were recruited from Hanyang University Guri Hospital for last 5 years. There were no positive results from allergy skin prick or serum test, but some of them showed positive food related history and food challenge tests. We applied CRD including pathogenesis-related protein family number 10 (PR-10) and non-specific lipid transfer proteins (nsLTP) for evaluating hidden allergens of AIU.
Results: There were no evidences with allergic skin and serum test for subjects. Twenty-four children of 74 subjects presented positive CRD results including PR-10 (apple (nMal d 1) 7, hazelnut (rConr a 1) 5, peach (rPru p 1) 4, peanut (rAra h 8) 4, kiwi (nAct d 8) 3, birch (rBet v 1) 4, alder (rAln g 1) 1), nsLTP (peach (nPru p 3) 4, hazelnut (rCor a 8) 3, mugwort (nArt v 3) 2), profilins (rBet v2) 3 children.
Conclusions: IgE sensitization to storage proteins in peanut, tree nuts or seeds is regarded as an important risk marker for severe systemic reactions. IgE sensitization to PR-10 or nsLTP may be shown to be the important allergen components for systemic reaction including AIU in childhood.