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Nut Allergy Prevalence and Differences Between Asian-Born Children and Australian-Born Children of Asian Descent: A State-Wide Survey of Children at Primary School Entry in Victoria, Australia.
Sunday, March 6, 2016
South Exhibit Hall H (Convention Center)
Katrina Jane Allen, FRACP, PhD, FAAAAI, Mary Panjari, PhD, Jennifer Koplin, PhD, Shyamali Dharmage, MD PhD, Rachel L Peters, MPH, PhD, Lyle Gurrin, PhD, Susan Sawyer, MBBS MD FRACP, Vicki L. McWilliam, BSc (MND) Adv APD, Jana K. Eckert, PhD, Don Vicendese, BSc, Bircan Erbas, PhD, Melanie C Matheson, PhD, Mimi L. K. Tang, MBBS PhD FRACP FRCPA FAAAAI, Jo Douglass, BMedSc (Hons), MBBS (Hons) MD FRACP, Anne-Louise Ponsonby, PhD, Terry Dwyer, PhD, Sharon Goldfeld, MBBS, FRACP, PhD
Rationale:

Asian infants born in Australia are 3 times more likely to develop peanut allergy than non-Asian infants and rates of challenge-proven food allergy in infants have been found to be unexpectedly high in metropolitan Melbourne. To further investigate risk factors for nut allergy we assessed the whole of State prevalence distribution of parent-reported nut allergy in 5 year old children entering school.

Methods:

Using the 2010 School Entrant Health Questionnaire administered to all 5 year old children in Victoria, Australia, we assessed the prevalence of parent-reported nut allergy (tree nut and peanut) and whether this was altered by region of residence, socioeconomic status, country of birth or history of migration. Prevalence was calculated as observed proportion with 95% confidence intervals (CI). Risk factors were evaluated using multivariable logistic regression and adjusted for appropriate confounders.

Results:

Nut allergy prevalence was 3.1% (95%CI 2.9-3.2) amongst a cohort of nearly 60,000 children. It was more common amongst children of mothers with higher education and socioeconomic index and less prevalent amongst children in regional Victoria than in Melbourne. While children born in Australia to Asian-born mothers (aOR 2.67 95%CI 2.28, 3.27) were more likely to have nut allergy than non-Asian children, children born in Asia who subsequently migrated to Australia were at decreased risk of nut allergy (aOR 0.1 95%CI 0.03, 0.31).

Conclusions:

Migration from Asia after the early infant period appears protective for the development of nut allergy. Additionally, rural regions have lower rates of nut allergy than urban areas.