Methods: Subjects with medically confirmed grass pollen-induced ARC for at least 2 years were enrolled in one of 4 natural field studies. All participants underwent prick skin testing to 5-grass mix or timothy and a panel of geographically relevant aeroallergens. Those who had a positive test to 5-grass/timothy and at least one other allergen were considered polysensitized. Each day, subjects self-scored each of their rhinitis symptoms (sneezing, rhinorrhea, nasal pruritus, nasal congestion) on a scale from 0 (none) to 3 (severe). The individual symptom scores and the Rhinitis Total Symptom Score (the sum of the four individual symptom scores) were analyzed descriptively.
Results: Data from 891 polysensitized subjects, corresponding to 65% of the studied population, were analyzed. The means of each of the individual symptom scores in the 300IR group (n=427) were significantly lower than in the placebo group (n=464) with relative differences from placebo of -15% (sneezing), -19% (rhinorrhea), -22% (nasal pruritus) and -24% (nasal congestion). The Rhinitis Total Symptom Score relative mean difference from placebo was -20%.
Conclusions: Oralair effectively reduced all rhinitis symptoms in polysensitized subjects with grass pollen-induced rhinoconjunctivitis.