Methods: This is a retrospective analysis of 1664 asthmatic patients; 189 were excluded due to other conditions that might interfere in sIgE, such as helminthiasis (n=1475). Skin prick tests (SPT) with standardized extracts of 11 allergens, FDA Allergenics® , were obtained in 663 patients. Tests were considered positive if wheal diameter was ≥ 3mm. Total serum IgE was determined by chemiluminescence. Asthma diagnosis and severity classified according to GINA 2014.
Results: 891 (60.4%) were male, median age 5.6 years (0.2 – 20 years); 86.8% had allergic rhinitis, 8% atopic dermatitis and 20.7% allergic conjunctivitis. 12.4% had no allergy-related comorbidities. Asthma was considered mild to moderate in 1165 (78.9%) and severe in 310 (21.1%). 362 (54.6%) had positive skin prick tests: 89.8% D. pteronyssinus; 70.7% B. tropicalis; 14.4% Lolium perenne; 8% B. germanica; 15.2% dog epithelium and 5.5% cat epithelium. There was a linear relationship between age and sIgE (p<0.001). The sIgE was similar in both mild to moderate and severe groups (p=0.72). Subjects with positive SPT had higher sIgE (p=0.004). Patients with severe asthma had more eosinophilia (p=0.001) and those with conjunctivitis had higher sIgE.
Conclusions: sIgE did not correlate with asthma severity and increased with age in this group.