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Patients from Low-Income Families Referred for Oral Food Challenge Were More Likely to Pass
Sunday, March 6, 2016
South Exhibit Hall H (Convention Center)
Koen R. Beukema, John Leung, MD, Yamini Virkud, MD, MA, MPH, Alice H. Shen, Sarita U. Patil, MD, Jyoti Ramakrishna, MD, Wayne Shreffler, MD PhD FAAAAI
Rationale: Previous studies indicate that the prevalence of food allergy may be influenced by income, but these are based on patient self-reports and/or physician diagnosis. We used oral food challenge (OFC) outcomes to study the relationship between income and food allergy. We hypothesized that confirmed food allergy would correlate with higher income.

Methods: We retrospectively analyzed OFC data collected at Tufts Medical Center and Massachusetts General Hospital between March 2008-April 2015. Household income (HHI, ≤$50,000/yr or >$50,000/yr) was estimated using median income of the patient home zip code. We used uni- and multivariable logistic regression to analyze for associations to outcome.

Results: Analysis of 1252 OFCs in 831 patients was performed. Most were male (57%) and white (79%), with an average age of 10 years (0.7-77.8). OFCs for major allergens (milk, egg, peanut, tree nuts, soy, wheat, fish and shellfish) accounted for 89% of the total. Ninety-three percent of the families were in the high HHI bracket. OFC outcomes were 26% positive, 69% negative, and 5% indeterminate. OFC outcome was associated with HHI (p=0.008) and allergen (major vs. non-major, p=0.039), but not with age (p=0.15), gender (p=0.08), race (p=0.30) or facility (p=0.52). We found that the low HHI group was 2.7 times more likely to have a negative OFC (CI=1.2-5.9, p=0.015), after controlling for allergen type, facility, age, gender, and race.

Conclusions: Patients from families with low HHI (≤$50,000/yr) are 2.7 times more likely to have a negative OFC compared with high HHI group (>$50,000/yr). Further studies are needed to determine the causality.