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Analysis of Anaphylaxis Trigger Factors and Treatment during a Five Year Period in a Vilnius University Hospital
Saturday, March 5, 2016
South Exhibit Hall H (Convention Center)
Audra Blaziene, Neringa Buterleviciute, Viktorija Paltarackiene, Lawrence M. DuBuske, MD, FAAAAI
Rationale: Anaphylaxis is increasing worldwide in prevalence. The World Allergy Organization criteria emphasize the rapid onset and multiple signs and symptoms of anaphylaxis. The aim of our study was to analyse anaphylaxis, based on WAO criteria, and to evaluate trigger factors, clinical patterns and treatment of anaphylaxis in a Vilnius, Lithuania hospital.

Methods: Patients with anaphylaxis hospitalized in Vilnius University Hospital Santariskiu Klinikos over five year period (2009–2014) were assessed. 103 patients (57: 55.34% women/46: 44.66% men) were noted to have anaphylaxis. The mean age of patients was 45.77 (range 20–83) years.

Results: The most frequent suspected triggers were drugs (39 cases: 37.86%), mainly NSAIDS (17 cases); insect stings (31cases: 30.09%); and food (5 cases: 4.85%). Anaphylaxis ocurred most commonly in summer (38 cases: 35.7%). The cardiovascular system (94 cases: 91.26%) and skin (90 cases: 88.26%) were impacted most frequently, followed by respiratory (56 cases: 54.34%) and gastrointestinal (23 cases: 22.33%) systems. Epinephrine as an initial treatment was administered for 61 (59.22%) patients. 37 (35.92%) patients were treated in the intensive care unit.

Conclusions: Drugs were the main suspected triggers of anaphylaxis. Cardiovascular symptoms were the most frequent, followed by the skin and respiratory symptoms. One third of patients were treated in the intensive care unit. Use of epinephrine as initial therapy remains less than expected considering the recent guidelines advising its use as intial treatment.