The Effect of Vitamin D Levels on Pediatric Allergic Diseases: A Nationwide Population-Based Study
Saturday, March 5, 2016
South Exhibit Hall H (Convention Center)
Hea-Kyoung Yang, Jaehee Choi, Woo Kyung Kim, So-Yeon Lee, MD, Yong Mean Park, Man-Yong Han, MD, Myung-Il Hahm, Yoomi Chae, Hye-young Kim, Kang Mo Ahn, MD, Ho-Jang Kwon, MD PhD, Jihyun Kim, MD
Rationale:  We aimed to investigate the association between concentration of serum vitamin D levels and recent symptoms of allergic diseases in elementary schoolchildren.

Methods:  A nationwide cross-sectional survey was conducted in the first grade students from randomly selected 45 elementary schools. Recent symptoms of atopic dermatitis (AD) or asthma were defined as those who were medically treated for AD or asthma. Recent symptoms of allergic rhinitis (AR) were considered to be present if a child had the experience of treatment for AR during the last 12 months and showed a positive skin prick test responses to common 18 inhalant allergens. All the children were examined by a pediatrician to determine the presence of eczema in their neck and flexural areas of both arms. Serum 25-hydroxyvitamin D [25(OH)D] was measured by chemiluminescent microparticle immunoassay.

Results:  The overall prevalence rates of vitamin D insufficiency (20 to 29 ng/mL) and deficiency (<20 ng/mL) were 64.1% and 18.4%. The adjusted odds ratio (aOR) for the presence of AR was 0.980 (95% CI: 0.962–0.998) for each increase of 1 ng/mL in 25(OH)D, while no association was found between 25(OH)D levels and the prevalence of AD or asthma. The aOR per increase of 1 ng/mL in 25(OH)D was 0.974 (95% CI 0.955-0.994) for the presence of eczema on the day of survey.

Conclusions:  A high prevalence of vitamin D deficiency and insufficiency was found in Korean elementary schoolchildren, and vitamin D level was associated with recent symptoms of AD and AR.