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Study of Relevant Allergens in Children and Adults with Lentil Allergy in a Population of Madrid Compared to Those with Allergy to Lentil and Peanut.
Monday, March 7, 2016
South Exhibit Hall H (Convention Center)
Maria Luisa Somoza, MD, Natalia Blanca-López, MD PhD, Diana Perez Alzate, MD, Maria Isabel Garcimartin, MD, Francisco Javier Ruano, Maria Vazquez De La Torre, MD, Elisa Haroun, MD, Francisca Gómez, MD, PhD, Cristobalina Mayorga, PhD, Ana Aranda, PhD, Miguel Blanca, MD, PhD, Gabriela Canto, MD, PhD
Rationale:

Legumes are the sixth leading cause of Food Allergy, being Lentil the most frequently involved in the Mediterranean.

Aim: to analyze Allergy to Lentil and the relation with Peanut allergy.

Methods:

We studied 1,375 patients (368 children/1,007 adults) from 2012-2014.

Allergological evaluation: clinical history, skin test, sIgE (immunoCAP) and OFC were performed.

Results:

Twenty-one children and 10 adults were allergic to Lentil, and 6 children and 4 adults to Lentil and Peanut. Group 1: symptoms after the introduction of Lentil (1–2 yo); Group 2: occasionally Lentil tolerance (3–19 yo); Group 3: well-established tolerance (20–51 yo).

Positive results by molecular allergens in patients with URT/AE and ANAP by Lentil:

Allergic to Lentil:

Group 1 (n=7): Ara h1: 57%; Ara h2: 43%; Ara h3: 0%; Pru p3: 0%.

Group 2 (n=8): Ara h1: 50%; Ara h2: 12%; Ara h3: 0%; Pru p3: 25%.

Group 3 (n=4): Ara h1: 50%; Ara h2: 50%; Ara h3: 0%; Pru p3: 50%.

Allergic to Lentil and Peanut:

Group 1 (n=1): Ara h1: 100%; Ara h2: 100%; Ara h3: 0%; Pru p3: 0%.

Group 3 (n=1): Ara h1: 100%; Ara h2: 100%; Ara h3: 0%; Pru p3: 100%.

Conclusions:

In this study molecular analysis results indicate that there is no recognition and/or low cross reactivity.

Ara h1 is most frequent in those patients with URT/AE to Lentil, and Pru p3 in those with ANAP.

No differences have been found in patients allergic to Lentil and allergic to Lentil and Peanut, but further studies are needed with more patients.