868
Association of Peripheral Blood Nave and Memory T Cells Markers from Immigrants to Brooklyn Who Develop Asthma/Allergies with Family History of Cancer.
Monday, March 7, 2016
South Exhibit Hall H (Convention Center)
Irina Katayeva, MD, Maria-Anna Vastardi, MD, Rauno Joks, M.D.
Rationale: Immigrants to Brooklyn from regions of low allergy/asthma prevalence who develop asthma and allergy have a less robust Th1 responses than those who remain healthy. We determined whether this profile extends to history of familial malignancies, as malignancies are associated with defective immune surveillance of cancer.      

Methods: Immigrants to Brooklyn (Chinese and Hispanic, n=112) with self-reported asthma and/or seasonal allergies and controls (asthma/allergy, n=57;  control, n=55) had blood drawn for determination of total serum IgE (fluoroimmunoenzyme assay)  and concurrent peripheral blood leukocyte memory markers: stem cells (CD35+),  CD4+ and CD8+ T cells: naïve (CD4+, CD8+; CD45RO-CD62LhiCD11alo), and CD28- memory (CD28-CD45RO+)(flow cytometry, LSR Fortessa, BD).  The history of cancer in first-degree relatives was obtained. Chi-square test and Pearson correlations were calculated.

Results: Those with asthma/allergies had significantly higher levels of IgE (p=0.016)

Increased percent of naïve T cell significantly associated with decreased percent of memory T cells for the following subsets: asthma/allergy CD4+ and CD8+ (p=0.008 and 0.001, respectively) and control CD4+ (p=0.003). No significant association was found for control memory CD8+ cells (p=0.25).

There was no difference in total number of malignancies in control vs. allergy subjects (n=13,13, p=ns), paternal cancer (n=5,5, p=ns), and self, sibling, or children (p=ns). However, maternal cancer was reported by only 1 control but by 6 allergic subjects (p=0.057).

Conclusions: Taken together, our findings suggest that a lack of robust Th1 responses in immigrants who develop allergic disease may be genetic and extend to defective cancer immune surveillance.