Methods: Anonymous survey was administered online to the parents of children with FPIES and IgE-FA. The economic impact survey (adapted from Gupta al., 2013), assessed direct medical, out-of-pocket, and indirect costs.
Results: Sixty-one FPIES responses and 131 IgE-FA responses were analyzed. In the past year, children with FPIES had 436 outpatient visits, 36 emergency room visits, and 18 hospitalizations versus 290 outpatient visits, 33 emergency room visits, and 2 hospitalizations for children with IgE-FA allergies. Out-of-pocket health-related costs were $7233 per child with FPIES, compared to $5029.8 per child with IgE-FA, P<0.001. The largest expense for FPIES families was special diets, $2583.4 per child, while for the IgE-FA families the largest expense was education and supervision, $1531 per child. In the past year, FPIES families missed an average 8.4 days of school and/or work versus average 4.8 days missed school and/ or work days for IgE-FA families, P=0.007. However, four FPIES families stated they had to give up their job in order to look after their child and reported an average salary loss due to FPIES as $75,000/family.
Conclusions: Childhood FPIES and IgE-FA result in significant self-reported direct and indirect costs for health care systems and families.