Methods: Records of 50 recent patients from an academic outpatient practice that have confirmed moderate to severe chronic DG were reviewed in regards to the presence of AD and various other atopic/related non-atopic disorders.
Results: The majority of these patients had a pruritic skin disorder as their presenting complaint whereas others had coexisting DG or developed this condition during the evaluation and treatment of other atopic/related non-atopic disorders. 31/50(62%) have concurrent AD. Of these patients, 8/12(67%) that were questioned specifically found that treatment of the AD was helpful in controlling the DG. Only 2/50 (4%) also have other physical urticarias (PUO) and only 1/50 (2%) have delayed pressure urticaria (DPU). 20/50(40%) have nonphysical urticaria (NPU) and 13/50(26%) have angioedema. 40/50(80%) of the patients have rhinosinusitis/conjunctivitis and 33/50(66%) have asthma. 14/50(28%) have concurrent food sensitivity.
Conclusions: Most DG patients have concurrent AD with treatment of the AD helpful in controlling the DG. Most DG patients do not have concurrent PUO or DPU but many have NPU. However, most DG patients have respiratory/ocular diseases and a significant number have food sensitivity, though this is not necessarily causative. Dermatographism, in addition to atopic dermatitis, should be considered as a potential dermatologic manifestation of atopic/related non-atopic disorders.