Methods: The Food Allergy Quality of Life Parental Burden (FAQL-PB) index, Food Allergy Self-Efficacy Questionnaire (FASEQ), and a questionnaire assessing the individual’s food allergy history were administered to n=115 caregivers of peanut, tree nut, milk, and egg allergic children who underwent OFCs between 2001 and 2012 at a referral center, and n=305 unchallenged children. Questionnaire data were verified through chart review.
Results: Mean FASEQ score was higher (worse) in the challenged vs. non-challenged population (3.81 vs. 4, p=0.02), but not significantly different based on allergen, anaphylaxis, or age. Within the OFC group, no difference in FASEQ score was noted based on challenge outcome, allergen, presenting symptoms, or age. FASEQ score was negatively correlated with FAQL-PB score (r=-0.38, p<0.001). In an adjusted regression model, OFC and FASEQ were not associated. However, the addition of FASEQ score to a previous model demonstrating a significant relationship between OFC and better QoL strengthened this association, while explaining an additional 9% of the total variance in QoL (adj.R2=0.3) in the population.
Conclusions: Caregiver SE is worse in challenged vs. non-challenged populations but unaffected by OFC outcome or allergen. In adjusted models, OFC has no significant effect on SE, but SE significantly moderates the effect of OFC on QoL.