Long-Chain Polyunsaturated Fatty Acid Intake in Children with Eosinophilic Esophagitis
Monday, March 7, 2016
South Exhibit Hall H (Convention Center)
Alison M. Cassin, MS RD CSP, Carina Venter, PhD RD, Kara Kliewer, PhD RD, Kate Maslin, MSc, RD, Marc E. Rothenberg, MD PhD FAAAAI
Rationale:  Omega-3 fatty acids, α-linolenic (ALA), docosahexanoic (DHA) and eicosapentaenoic acid (EPA) are important immune modulators. The role of these fatty acids in atopic conditions is well established. To date, their role in eosinophilic esophagitis (EoE) has not been investigated. Elimination diets are common therapy for EoE, and depending on the diet prescription, may exclude omega-3-rich foods such as nuts (ALA) and seafood (DHA & EPA) from the diet. In this study we aim to compare omega-3 fatty acid intake of EoE patients following restricted diets to the general population of a similar age range.

Methods:  Three-day food records were collected from new patients (n=78) seen at the Cincinnati Center for Eosinophilic Disorders and analyzed by a registered dietitian.  Each patient had a confirmed EoE diagnosis based on 2011 consensus guidelines. Mean ALA, DHA and EPA intake was compared to age-matched reference data from the National Health and Nutrition Examination Survey (NHANES) by unpaired t-test.

Results:  In this cohort of EoE patients (n=78), dietary intake of ALA (mean=0.50g), DHA (mean=0.02) and EPA (mean=0.007g) were lower than reference data from NHANES (n=8604), with ALA (mean=1.4g; p=0.0043; 95% CI: 0.288-1.519), and DHA (mean=0.07 g; p=0.0001; 95% CI:  0.045-0.055) but not EPA (mean=0.03g; p= 0.031; 95% CI:  0.002-0.044) reaching significance.

Only 1 of 78 subjects was taking an omega-3 supplement.

Conclusions:  Children with EoE have lower intake of omega-3 fatty acids than national-survey controls and therefore may benefit from a referral to a registered dietitian for nutritional assessment.