Eassi Survey: European Multicentre Prospective Study to Collect Systemic Adverse Reactions Due to Allergen Immunotherapy: Pediatric Population Results
Sunday, March 6, 2016
South Exhibit Hall H (Convention Center)
Pablo Rodriguez Del Rio, Carmen Vidal, MD PhD, Jocelyne Just, MD PhD, Oliver Pfaar, MD, Pascal M. Demoly, PhD, MD, Moises A. Calderon, MD PhD

Systemic adverse reactions (SAR) due to Allergen Immunotherapy (AIT) still represent one of its major drawbacks preventing a more extensive use of this etiologic treatment. The objective of this EAACI-supported survey was to collect SAR due to aeroallergen AIT in real life practice


Data was centrally collected with an online database, and gathered through three different questionnaires: DQ: doctor questionnaire (filled in only once by each participant doctor), PQ: patient questionnaire (one per patient-treatment) and RQ: reaction questionnaire (one per reaction). Harmonized MedDRA terminology for SAR due to AIT was used


Three countries (France, Germany and Spain), 95 doctors and 1578 pediatric patient-treatment were recruited, mean age 11.7 years(+/-SD 3.9), 59.1%(932) males. Allergic asthma and rhinitis/rhinoconjunctivitis was the AIT indication in 56.1%(886) patients, allergic rhinitis/rhinoconjunctivitis without asthma in 38.3%(604), asthma alone in 5.2%(82) and conjunctivitis alone in 0.4%(6) patients. Monoallergen AIT composition was 49%mites, 25.8%grass, 8.7%tree, 4.6%Alternaria, 0.8%epithelia, 0.6%weeds and 10.5% were mixtures. Subcutaneous AIT (SCIT) was used in 71.4% (n=1127). A total estimation of 19.669 and 131.550 doses of SCIT and sublingual AIT (SLIT) were given, and 29 SAR (79.3%SCIT) were recorded in 24 patient-treatments, 3 were anaphylaxis and only 1 was severe. SAR were more frequent in up-dosing (79.3%) but milder (82.6%mild) than in maintenance (33.3%mild) (p= 0.023). The use of natural extracts compared to allergoids was associated with higher risk of suffering SAR (OR=8.4, 95%CI: 1.9-36.5)


AIT showed to be a safe treatment with a low rate of SAR and even lower ratio of severe SAR