Comparison of Omalizumab Therapy Effectiveness in Patients with Hypersensitivity to Non-Steroidal Anti-Inflammatory Drugs (NSAID) and Patients Who Tolerate NSAID (non-NSAID) Polish Real Life Experience
Sunday, March 6, 2016
South Exhibit Hall H (Convention Center)
Izabela R. Kuprys-Lipinska, MD PhD, Pawel Majak, MD PhD, Joanna Molinska, M. Sc., Mateusz Jonakowski, Student, Piotr Kuna, MD PhD
Rationale: Hypersensitivity to non-steroidal anti-inflammatory drugs (NSAID) is a distinct phenomenon of severe asthma, but may coexists with allergy. The aim of the analysis was to compare the effectiveness of omalizumab (OMA) in the treatment of severe allergic asthma in patients with hypersensitivity NSAID to patients who tolerate NSAID (non-NSAID).

Methods: 38 patients started OMA therapy in the Polish program for the treatment of severe allergic asthma in Barlicki Hospital between 2013 and 2015 year. We prospectively evaluated OMA effectiveness recording changes in oral corticosteroids daily dose (OCS), annual numbers of asthma exacerbations, the Asthma Control Questionnaire (ACQ) score, and the Asthma Quality of Life Questionnaire (AQLQ) score in 16th week and 52nd week of therapy. At the baseline the positive history of hypersensitivity to NSAID was reported by 14 patients, 24 patients tolerated NSAID.

Results: The baseline characteristic of study groups in respect of demographic data, anthropologic data and severity of asthma did not significantly differed between NASID and non-NASID (P>0,05). 4 patients (2/2 from NASID/non-NASID) stopped themselves the therapy due to subjective lack of benefit. In both groups we observed significant improvement in ACQ, AQLQ scale as well the reduction of exacerbations and the OCS dose in 16th and 52nd week (P<0,05). The improvement in asthma control parameters between study groups did not differed in 16th and 52nd week (P>0,05).

Conclusions: The OMA seems to be equally effective in patients suffering from severe allergic asthma independently of NSAID hypersensitivity status, but larger population study is required to confirm this observation.