706:
Clinical, Endoscopic and Histopathological Characteristics of Pediatric Patients with Eosinophilic Digestives Diseases attending the Gastroenterology Department of the National Institute Of Pediatrics in Mexico City
Monday, March 5, 2018
South Hall A2 (Convention Center)
Amyra Ali Azamar Jacome, MD, Josefina Monserrat Cazares Mendez, David Alejandro Mendoza Hernandez, Jose G. Huerta Lopez, MD FAAAAI
RATIONALE:

Eosinophilic digestive diseases (EDD) are rare disorders characterized by gastrointestinal eosinophilic infiltrates without underlying primary etiology. Its pathogenesis remains unclear, but is suspected to be related to an hypersensitivity reaction given its relation with other allergic disorders and clinical response to steroid therapy. The objective of this study was to describe the clinical and paraclinical profile of pediatris patients with EDD.

METHODS:

We conducted a retrospective, observational, transversal and descriptive study, in wich we reviewed every histopathological report of patients who underwent endoscopy and/or colonoscopy in the Gastroenterology department of the National Institute of Pediatrics in Mexico city from 2014 to 2016. EGE was defined by biopsies showing eosinophilic infiltration of at least 20 eosinophils per high power field, according to Talley criteria. Socio-demographic, clinical and treatment data were searched in the clinical files and registered.

RESULTS:

EDD was diagnosed in 27 patients, average age was 5±4.6. 72% of patients had evidence of food sensitization (14% IgE mediated and 86% non IgE-mediated): 81% cow’s milk allergy, 19% egg allergy and 11% to others. Most frequent symptoms were: pain (50%); regurgitation, vomit and diarrhea (30%); dyschezia, constipation and bleeding (25%). Eosinophilic duodenitis was the most common EDD (59%), followed by eosnophilic esophagitis (26%) and eosinophilic colitis (18.5%); 22% had combined forms of EDD.

CONCLUSIONS:

EDD are poor studied entities that may be more frequent that thougt. In our study two thirds of patients had evidence of food allergy. More studies should be adressed in order to better understand this entity.