Clinical and laboratory characteristics of children with nasal polyposis
Saturday, March 3, 2018
South Hall A2 (Convention Center)
Kevin Li, Nadeem Akbar, MD, Waleed M. Abuzeid, MD, Denisa E. Ferastraoaru, MD
RATIONALE: Nasal polyposis (NP) is rare in children and is described mostly in association with primary ciliary dyskinesia (PCD) or cystic fibrosis (CF). We sought to investigate any clinical and laboratory differences between children and adults with NP seen at our institution.

METHODS: Clinical Looking Glass was used to retrospectively collect data from medical records of patients with NP seen at Montefiore Medical Center, Bronx, NY between 2010-2016. For those who had NP surgery, histopathological results were reviewed.

RESULTS: Of the 2038 patients with NP, 144/2038 (7%) were children (mean age 11.4 years, ±4.9) who had higher rates of male gender compared to adults (56% vs. 46%, p=0.023). Diagnoses of PCD were found in two adults and CF in one child and two adults. The prevalence of asthma was similar in children and adults with NP (35% vs. 39%, p=0.36). In total 19/144 (13%) children and 307/1894 (16%, p=0.34) adults underwent surgery for NP. In these patients, the histopathological examination revealed predominantly inflammatory polyps followed by allergic polyps with high eosinophilic infiltrates in both age groups. Comparable high levels of serum eosinophil count and total IgE were found in children (280 cells/uL, ±48; 401 kU/L, ±509) and adults (300 cells/uL, ±34; p=0.24; 382 kU/L, ±733; p=0.9).

CONCLUSIONS: Compared with adults, children with NP were predominantly male. Similar rates of asthma diagnosis, allergic polyps on histopathological exam and high levels of serum allergic markers in children and adults with NP suggest a shared phenotype with potential treatment implications.