METHODS: A review of patients in a single large-scale pediatric primary care population was performed. ICD 9 and 10 codes for patients with EoE compared to patients without EoE were used to differentiate prevalence rates for coexisting diagnoses.
RESULTS: A cohort of over 455,000 children with 428 patients with EoE was reviewed. Median age of EoE diagnosis was 7.7 years. Significant differences in prevalence rates for atopic diseases were found between the two cohorts: Allergic rhinitis EoE vs No EoE (60.0% vs 17.4%, P<0.0001); Asthma EoE vs No EoE (59.8% vs 21.4%, P<0.0001); Eczema EoE vs No EoE (17.8% vs 6.6%, P<0.0001). Significant differences for other comorbid conditions included: Autism Spectrum Disorder EoE vs No EoE (7.5% vs 1.9%, P<0.0001); Celiac Disease EoE vs No EoE (5.6% vs 0.9%, P<0.0001); Inflammatory Bowel Disease EoE vs No EoE (0.7% vs 0.2%, P=0.02); Adrenal Insufficiency EoE vs No EoE (2.6% vs 0.4%, P<0.0001); Connective Tissue Disease EoE vs No EoE (1.4% vs 0.1%, P<0.0001); Type 1 Diabetes Mellitus EoE vs No EoE (1.2% vs 0.3%, P=0.0007). Comorbid hypothyroidism was not significantly different between groups: EoE vs No EoE (0.5% vs 0.4%, P=0.74).
CONCLUSIONS: Children with EoE hold higher rates of comorbid diagnoses for various conditions compared to those without EoE in a single primary care population.