340:
Allergic Sensitization and Asthma Severity
Sunday, March 4, 2018
South Hall A2 (Convention Center)
Yoavanit Srivaro, MD, Jettanong Klaewsongkram, MD, Hiroshi Chantaphakul, MD FAAAAI
RATIONALE: The prevalence of asthma is increasing. Allergy is one of the risk factors for respiratory symptoms. The primary objective of this study is to evaluate the correlation between aeroallergens sensitization and asthma severity.

METHODS: All asthma patients came to Allergy Clinic during January 2015 to February 2016 were screened. Those met inclusion criteria were recruited. They were asked to complete a questionnaire. Demographic data were collected. Physical examination, pulmonary function and skin prick test were performed in every subject.

RESULTS: Eighty patients were enrolled. The mean age was 45 years. Seventy percent of subjects were female. One third had positive skin test to more than five allergens. The positive results were as follow; Dermatophagoides farinae 72.5%, Dermatophagoides pteronyssinus 71.25%, cockroach 50%, cat 48.75% and mold mixed 27.5%. There were 34 mild, 39 moderate and 7 severe asthma cases. The number of positive skin test was correlated with asthma severity (r = -0.422, P<0.001). Sensitized to more than five allergens was associated with 11-fold increases in the odds of having more asthma symptoms. Positive test to Dermatophagoides farinae, cat and cockroach had 3-fold increases of severe asthma. Subjects live in urban area were three times more likely to have moderate or severe asthma.

CONCLUSIONS: The number of skin test positivity is correlated with level of asthma severity. Subjects with positive skin test to mite, cat and cockroach were likely to have more asthma symptoms. The patients live in urban area had greater chances of having moderate to severe asthma.