14:
Effect of Birth Weight on Lung Function and Exhaled Nitric Oxide in A Cohort of Asian Children at Six Years of Age
Saturday, March 3, 2018
South Hall A2 (Convention Center)
Wan-Fang Lee, Chun-Chun Gau, I-Chun Lu, Li-Lun Lin, Chao-Yi Wu, MD PhD, Hui-Ju Tsai, Tsung-Chieh Yao
RATIONALE: Although low birth weight has been linked to reduced lung function in children in previous studies, there is a paucity of research in this area among Asian populations. Our aim was to evaluate how birth weight affects lung function measurements and fraction of exhaled nitric oxide (FeNO) in Asian children.

METHODS: We used data for 385 Asian children (201 boys, 54.5%) from the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) cohort to determine the association of birth weight with lung function parameters and FeNO levels at 6 years of age, adjusted for gestation age, sex, age, current height, maternal smoking during pregnancy, and maternal asthma.

RESULTS: Birth weight was significantly positively associated with forced vital capacity (FVC) (p=0.026), forced expiratory volume in 1 second (FEV1) (p=0.025), peak expiratory flow (PEF) (p=0.029), and forced expiratory flow at 25-75% (FEF25-75) (p=0.042), but not with the FEV1/FVC ratio (p=0.508), after adjusting for confounders. In subgroup analysis stratified by physician-diagnosed asthma, birth weight was positively associated with FVC, FEV1, and PEF in children without asthma, but not in children with asthma. A consistent pattern of association between birth weight and post-bronchodilator lung function parameters was observed. There was no significant association between birth weight and FeNO levels, after adjusting for confounders.

CONCLUSIONS: Birth weight is significantly associated with lung function in this cohort of Asian children at school age, while the effect is mostly confined to children without asthma. Birth weight has no obvious effect on FeNO levels in Asian schoolchildren.