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Factors associated with severe asthma exacerbation in children: Preliminary Report
Sunday, March 4, 2018
South Hall A2 (Convention Center)
Isree Leelayuwattanakul, MD, Punchama Pacharn, MD, Orathai Jirapongsananuruk, MD, Nualanong Visitsunthorn, MD
RATIONALE: Severe asthma exacerbations affect quality of life. This study aimed to identify factors that associate with severe asthma exacerbation in Thai children.
METHODS: The case-control study was performed in children admitted due to severe asthma exacerbation (inpatient department; IPD). The control group was asthmatic children who had no admission in the previous year (outpatient department; OPD). Skin prick test (SPT) of 16 common aeroallergens in Thailand was performed. Possible risk factors were analyzed.
RESULTS: Thirty-six patients, 13 IPD cases (36.1%) and 23 OPD cases (63.9%), with the mean age of 7.8 ± 3.2 years were included. Allergic rhinitis was found in 91.4% of the cases. Thirteen patients (36.1%) were categorized as mild persistent asthma, 20 patients (55.6%) as moderate persistent asthma, and 3 patients (8.3%) as severe persistent asthma. No statistically significant difference in age, gender, severity, obesity status, other allergic diseases, family history of atopy, or familial income was found between the IPD and the OPD groups. History of emergency room (ER) visit (≥1 time/year) in the past year was found in 13/13 patients (100 %) in the IPD group compared with 10/23 patients (43.5%) in the OPD group (P=0.001). The SPT positivity of fungal allergen extracts in the IPD group was 8/13 patients (61.5%) compared to 6/23 patients (26.1%) in the OPD group (P=0.036).
CONCLUSIONS: The preliminary data showed that the history of ER visit due to asthma exacerbation in the past year and positive SPT of fungal allergen extracts were associated with severe asthma exacerbation in children.