733:
Serum periostin levels associates to secondhand tobacco smoke exposure and exercise in children
Monday, March 5, 2018
South Hall A2 (Convention Center)
Sung Myong Soon, Lee Kyung Suk, Han Man Yong, Baek Hey Sung, Izuhara K
RATIONALE: Recent studies have suggested an important role for periostin in the pathogenesis of allergic disease. However, serum periostin levels are limited by lack of reference range values and influencing factors in children.

METHODS: This cross-sectional study examined 1,265 children from the general pediatric population who were first grade to sixth grade attended 6 elementary schools in Korea between June and July 2016. Of the 1,265 children, 249 children from first grade of elementary school were included randomly for the analysis.

RESULTS: The mean levels of periostin and eosinophil were 106.0 (interquartile range [IQR], 92.0 - 124.0) ng/mL and 3.2 (IQR 2.1 - 5.0) %, respectively. Serum periostin level was no significant difference in gender, body mass index status, eosinophil level, and 25-(OH)D3 status. After univariate linear regression, secondhand tobacco smoke (SHS) exposure in pregnancy was associated with a statistically significant increased risk of serum periostin level (aOR 1.890, 95% CI 1.047 – 3.410, P = 0.035), but no SHS exposure in afterbirth 1 year. Serum periostin level was not associated with current smoking dose and time of weaning. The frequency of exercise ≤ 2days/week was associated with a statistically significant increased risk of serum periostin level (aOR 2.134, 95% CI 1.211 – 3.761, P = 0.009).

CONCLUSIONS: Serum periostin levels may correlate with SHS exposure during pregnancy and frequency of exercise in children.