Sensitization pattern in a group of patients with allergic disease through a molecular diagnostic study using microassay-based multiplex technology (ISAC).
Monday, March 5, 2018
South Hall A2 (Convention Center)
Cesar F. Pozo Sr., Elsy M Navarrete, Blanca E Del Rio

Knowledgement of which allergens are sensitized in children aged 1-18 years with allergy symptoms in a group of patients who were given multiplex platforms (ISAC®).


This study has a transversal, observational, descriptive and retrolective design. All clinical records of patients with ISAC study were reviewed during the period from January 2016 to December 2016


Allergic diseases reported in order of frequency were: allergic rhinitis (60%), asthma (26%), and other allergic diseases were atopic dermatitis, urticaria and allergic conjunctivitis, and food allergy. In general, the most frequent sensitizations of seasonal aeroallergens were grasses (Phl d 1, Phl d 5, Phl d 11, Cyn d 1), and in less frequencies Ole e1, Cup a 1, Sal 1 and Che a 1, perennial allergens , Der f 2 and Der p 2 in more than 50% of patients, Lipocalins (Canf 1, Feld 4), a high frequency of sensitization was found in Bet v1 (PR-10) in 90% of patients, a pattern of Sensitization in 30% of respiratory nsLTPs with positive nsLTP from food without clinical relevance. Among the most frequent food allergens were Bos d8 (Casein), Gal d2 (ovalbumin), with 20% of sensitization in pocalcins (Bet v4, Phl 7).


The diagnosis of allergic components (natural or recombinant) is a great qualitative leap that allows a significant improvement in the diagnosis and treatment of allergic patients, it is of great importance to know the pattern of sensitization in each population.