738:
Sensitization pattern in a group of patients with allergic disease through a molecular diagnostic study using microassay-based multiplex technology (ISAC).
Monday, March 5, 2018
South Hall A2 (Convention Center)
Cesar F. Pozo Sr., Elsy M Navarrete, Blanca E Del Rio
RATIONALE:

Knowledgement of which allergens are sensitized in children aged 1-18 years with allergy symptoms in a group of patients who were given multiplex platforms (ISAC®).

METHODS:

This study has a transversal, observational, descriptive and retrolective design. All clinical records of patients with ISAC study were reviewed during the period from January 2016 to December 2016

RESULTS:

Allergic diseases reported in order of frequency were: allergic rhinitis (60%), asthma (26%), and other allergic diseases were atopic dermatitis, urticaria and allergic conjunctivitis, and food allergy. In general, the most frequent sensitizations of seasonal aeroallergens were grasses (Phl d 1, Phl d 5, Phl d 11, Cyn d 1), and in less frequencies Ole e1, Cup a 1, Sal 1 and Che a 1, perennial allergens , Der f 2 and Der p 2 in more than 50% of patients, Lipocalins (Canf 1, Feld 4), a high frequency of sensitization was found in Bet v1 (PR-10) in 90% of patients, a pattern of Sensitization in 30% of respiratory nsLTPs with positive nsLTP from food without clinical relevance. Among the most frequent food allergens were Bos d8 (Casein), Gal d2 (ovalbumin), with 20% of sensitization in pocalcins (Bet v4, Phl 7).

CONCLUSIONS:

The diagnosis of allergic components (natural or recombinant) is a great qualitative leap that allows a significant improvement in the diagnosis and treatment of allergic patients, it is of great importance to know the pattern of sensitization in each population.