Cord Blood Soluble Fas Ligand Predicts Allergic Rhinitis, Obstructive-type Lung Function, and Mite Sensitization at Seven Year-old Children: The PATCH study
Sunday, March 4, 2018: 4:30 PM
South Hall A2 (Convention Center)
Kuan-Wen Su, MD, Kuo-Wei Yeh, MD FAAAAI, Jing Long Huang, MD
RATIONALE: Cord blood soluble Fas ligand (sFasL), an innate immunity marker, was related to asthma, allergic rhinitis, and atopic dermatitis at some cross-sectional or short-term follow-up studies. The Prediction of Allergies in Taiwanese Children (PATCH) study is a birth cohort study, focusing on the epidemiology and predictive factors of asthma and allergies in children. So, we investigated the relationship of cord blood sFasL and allergic outcomes in this long-term follow-up birth cohort study.

METHODS: The PATCH study recruited 258 pregnant women for a prospective birth cohort study. Umbilical cord bloods were collected at birth. At the age of seven, children’s allergic outcomes (e.g. asthma, allergic rhinitis, and atopic dermatitis) were diagnosed by pediatric allergists. Blood tests, fractional exhaled nitric oxide (FeNO) tests, and pulmonary function tests were conducted. Independent t test and linear regression were used for analyses.

RESULTS: 132 (51%) children were followed up until 7 year-of-age. Cord blood sFasL levels were higher in children with allergic rhinitis (p=0.012) and expiratory airflow limitation (FE1/FVC<90%, p=0.022). FeNO levels at 7 year-of-age were highly correlated with cord blood sFasL levels (p=0.006). Children with atopy (immunoglobulin E levels more than 100kU/L) and house dust mite sensitization had higher cord blood sFasL levels (both p=0.003).

CONCLUSIONS: At this birth cohort, cord blood sFasL levels were associated with allergic rhinitis, obstructive-type lung function, FeNO, and house dust mite sensitization at 7 year-old children. Cord blood sFasL level might be used as a predictor for future allergic outcomes at 7 year-of-age.