METHODS: this case-control study included 50 CU adults and 100 controls. The levels of these biomarkers were quantified by ELISA. Normal reference values for this study: VitD 30 to 100 ng/ml, leptin 1 to 15 ng/ml and adiponectin 5 to 30 ug/ml. p-values <0.05 was considered statistically significant.
RESULTS: female gender is showing as a risk factor for CU OR:2.45 (95%CI: 1.09 to 5.4; p:0.022). The majority of cases were female (80%; n:40/50). Insufficient levels of VitD seems to be a risk factor for CU. OR:7.67 (95%CI: 3.3 to 17.3; p:0.00). Seventy six percent (n=38) of the cases showed high levels of leptin unlike controls (10%; n=10) (p: 0.000); OR:24.4 (95%CI: 9.04 to 65.9; p:0.00). Normal Levels of adiponectin was found in the CU group (92%; n:46/50), Also low levels of this adipokyne was found in the control group 34% (n:34/100)
CONCLUSIONS: This study showed that patients with CU had VitD insufficiency and that these low levels could increase susceptibility to CU. Our results Also showed an associación of high levels of leptin with CU consistent with the literature. More studies should be done in other populations to reproduce this result.