171:
Serum levels of leptin, adiponectin and vitamin D in Colombian adults with chronic urticaria.
Saturday, March 3, 2018
South Hall A2 (Convention Center)
Luis Fang, DDS, MSc., Eduardo Egea, MD, PhD, Nicole Pereira-Sanandres, Fernando R De la cruz-Lopez, Sofia Moreno-Woo, Gloria Garavito-De Egea, MD, PhD
RATIONALE: chronic urticaria (CU) is a complex disorder associated with a chronic systemic inflammation. This inflammation could be related with the release of adipokines with proinflammatory and anti-inflammatory properties. Vitamin D (VitD) deficiency has been associated with CU. The purpose of this study was to analyze the association between serum levels of VitD, leptin, and adiponectin with CU in Colombian Caribbean adults.

METHODS: this case-control study included 50 CU adults and 100 controls. The levels of these biomarkers were quantified by ELISA. Normal reference values for this study: VitD 30 to 100 ng/ml, leptin 1 to 15 ng/ml and adiponectin 5 to 30 ug/ml. p-values <0.05 was considered statistically significant.

RESULTS: female gender is showing as a risk factor for CU OR:2.45 (95%CI: 1.09 to 5.4; p:0.022). The majority of cases were female (80%; n:40/50). Insufficient levels of VitD seems to be a risk factor for CU. OR:7.67 (95%CI: 3.3 to 17.3; p:0.00). Seventy six percent (n=38) of the cases showed high levels of leptin unlike controls (10%; n=10) (p: 0.000); OR:24.4 (95%CI: 9.04 to 65.9; p:0.00). Normal Levels of adiponectin was found in the CU group (92%; n:46/50), Also low levels of this adipokyne was found in the control group 34% (n:34/100)

CONCLUSIONS: This study showed that patients with CU had VitD insufficiency and that these low levels could increase susceptibility to CU. Our results Also showed an associación of high levels of leptin with CU consistent with the literature. More studies should be done in other populations to reproduce this result.