169:
Healthcare Resource Utilization Among a US Cohort Treated for Hereditary Angioedema, 2010-2015
Saturday, March 3, 2018
South Hall A2 (Convention Center)
Raffi Tachdjian, Karin Johnson, Deborah Casso, Susan Oliveria, Giovanna Devercelli, Gagan Jain
RATIONALE: Hereditary angioedema (HAE), characterized by unpredictable, mild-to-severe or life-threatening swelling episodes, is associated with high healthcare resource utilization (HCRU). This analysis evaluated HCRU per person per year (PPPY) in a cohort of commercially insured patients treated for HAE.

METHODS:

Retrospective study using PharMetrics Plus™, a US administrative claims database. IRB review and informed consent for de-identified data were not required. HCRU was calculated among patients with 2 years of continuous enrollment from 2010 to 2015 based on diagnosis codes likely related to HAE (ICD-9-CM 277.6 or ICD-10-CM D84.1) and typical HAE treatments (C1-esterase inhibitors, ecallantide, icatibant, androgens, tranexamic acid, aminocaproic acid, fresh frozen plasma). All-cause and HAE-related HCRU patterns were analyzed using descriptive statistics. Mean (SD) are reported.

RESULTS: 538 patients met inclusion criteria. Number of all-cause claims by type of service were outpatient care (59.4[84.1]), including ancillary services (21.4[41.1]) and office visits (14.9[17.2]); emergency department visits (2.1[10.3]); inpatient admissions (0.4[1.0], with length of stay 7.0[15.0] days), and pharmacy services (37.1[45.0]). Number of HAE-related claims by type of service were outpatient care (15.7[46.8], including ancillary services (7.8[24.4]) and office visits (2.7[7.0]); emergency department visits (1.1[9.0]); inpatient admissions (0.2[0.6], with length of stay 4.3[6.6] days), and pharmacy services (7.9[11.2]). During the 2-year period, 36.6% and 22.3% of patients had claims for HAE-related emergency department visits and inpatient admissions, respectively. Among specialists analyzed, allergists were most frequently visited (all-cause visits (1.9[5.9]); HAE-related visits (1.1[5.2])).

CONCLUSIONS: This retrospective US study provides HCRU estimates and shows high utilization of various healthcare resources among patients treated for HAE.