53:
Prenatal and postnatal exposure to perfluoroalkyl substances and antibody concentrations with mass vaccination in 5, 8, 11 and 14 year-old children in Taiwan
Saturday, March 3, 2018
South Hall A2 (Convention Center)
Shu-Li Julie Wang, Shiang-Jen Jane Lin, Hui-Ju Wen, Yuliang Leon Guo
RATIONALE: Perfluoroalkyl substances (PFASs) are wide spread persistant compounds which have half-life of 3-15 years in human bodies. PHASs have been found associated with decreased toxoid antibody concentrations, and increased atopy risk in children. We aim to examine the association between PFASs exposure and children antibody levels.

METHODS: We utilized a birth cohort established in 2000-2001 consisting 610 pregnant women and their children followed at 2, 5, 8, 11, and 14 years old. Due to lost-to follow-up and lake of sufficient serum, 376 and 69 children have PFASs quantified at birth and 8-year old, respectively. Antibody concentrations were analyzed for 90, 104, 69 and 92 children at 5, 8, 11, and 14 years, respectively. The last time mass vaccination was during 5-6 year-old in Taiwan. Co-exposure of phthalate, inorganic arsenic, chromium and cadmium was considered.

RESULTS: PFOS and PFOA levels were generally slightly lower but PFNA was higher than in the US and northern Europe. High correlation and comparable PFASs and antibody concentrations between maternal and cord blood was established, apart from that cord blood had much higher PFHxS than maternal venous blood (median, 22.8 vs. 1.0 ng/mL). Preliminary results showed cord blood PFASs appear to associate with decreased antibody against tetanus, rubella and HBV. For example cord blood PFDoA was correlated with decreased tetanus antibody concentrations at 5 and 14 years, with r=-0.31 (p<0.01) and -0.37 (p<0.001), respectively.

CONCLUSIONS: Clinical management concerning re-booster of certain vaccinations may have PHASs exposure considered because children immune Th1/Th2 might be unbalanced. Further mechanistic study is warranted.