Positive antinuclear antibodies and elevated IgE
Sunday, March 4, 2018
South Hall A2 (Convention Center)
Vylma Velazquez, Ernesto Santini
RATIONALE: A recent study showed an association between elevated serum IgE and autoimmune diseases, and a relationship between high levels of IgE and Systemic Lupus Erythematosus disease. In our clinical experience, we found several atopic patients with elevated IgE and positive antinuclear antibody (ANA) without Systemic Lupus Erythematosus. The purpose of this study is to identify if there is an association between IgE levels and ANA positivity

METHODS: IRB approved, we reviewed 500 charts from an allergy clinic, with laboratory reports of IgE levels and ANA status, patients with SLE were excluded. 245(49%) records matched this inclusion criteria. We divided the records in two groups based on ANA status positive or negative. We studied gender, age and diagnosis of these patients. Statistical analysis was used for evaluation of association between IgE levels and positive ANA.

RESULTS:: Of 245 patients, 65% were females, 22% were between 5-11 years old, 93% were ANA negative. Most frequent allergy diagnosis were allergic rhinitis and atopic dermatitis. ANA positive patients were more frequent in urticaria and allergic rhinitis. Our data showed no significant difference in the mean IgE level between the ANA status.

CONCLUSIONS: In our study the association between IgE levels and ANA positivity was not demonstrated. There is still a lot that we do not know of the possible roles of IgE in the pathophysiology of autoimmune diseases, most of our positive ANA were found in urticaria patients and this should be investigated to stablish better diagnosis and treatment possibilities to manage conditions of autoimmunity