Association Between Maternal Prenatal Vitamin D Concentration And Child Asthma
Saturday, March 3, 2018
South Hall A2 (Convention Center)
Kecia N. Carroll, MD, Sarah N. Adams, MD, Tebeb Gebretsadik, MPH, Christina F. Ortiz, MD MPH, Margaret Adgent, PhD, Frances A Tylavsky, D.P.H, MS, BS, Terry J Hartman, PhD, MPH, RD

Asthma is a leading chronic disease among children in the U.S. Prenatal vitamin D may have a protective effect on child asthma, with differential relationship by maternal race.


We investigated the association of 2nd trimester prenatal vitamin D [25-hydroxyvitamin D (25(OH)D)] plasma concentrations and child asthma in dyads enrolled in Conditions Affecting Neurocognitive Development in Early Childhood (CANDLE) cohort (Memphis, TN). This analysis includes African American (AA) and white women, enrolled prenatally during 2006-2011, and term, non-low birth weight children. Current asthma was ascertained at 4-6 years (parent report of physician diagnosis and current [past 12 months] symptoms or asthma medication use, or current symptoms and medication use). We assessed for effect modification of log transformed prenatal 25(OH)D and child asthma by maternal race using multivariable logistic regression with covariates including maternal asthma, education, and child sex and birth season.


Of 964 women, 65% were AA and 12% had asthma. Median 25(OH)D) levels were 25.0 ng/mL and 19.35 ng/mL in white and AA women, respectively. In multivariable analyses that tested for interaction (p=0.023), an interquartile range increase (15-27 ng/mL) was associated with a protective trend in white women, (adjusted OR 0.62, 95% CI: 0.35-1.10, p=0.10) and reversed in AA women (adjusted OR 1.33, 95% CI: 0.93-1.90, p=0.12).


Our study suggests a potentially different relationship between prenatal vitamin D status and child asthma by maternal race, with a trend towards a protective effect in white women that is not seen in AA women.