392:
Iron Deficiency Reduces Systemic Inflammation in Obese Women
Sunday, March 4, 2018
South Hall A2 (Convention Center)
Igor Petrovich Kaidashev, MD, V Nedoborenko, T Mamontova, L Vesnina, Lawrence Dubuske
RATIONALE: Iron may impact immune function including stimulating immune responses Obesity (OB) is accompanied by chronic low-intensity inflammation and changes in the concentration of iron in the blood. The level of systemic inflammation may be impacted by iron deficiency anemia (IDA) in patients with OB

METHODS: 40 women average age of 40.3 ± 7.59 years with IDA (30 with OB and 10 without OB) and 10 with OB of a similar age (control group) participated in the study. Hemogram parameters, indicators of iron exchange (serum iron, ferritin, hepcidin, total iron binding ability of serum and saturation of transferrin by iron) and inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6) in serum were assessed.

RESULTS: CRP was significantly greater in controls compared with IDA (p <0.05) while IDA with versus without OB were similar (p> 0.05). IL-6 was greater in the controls versus IDA (p <0.05) and in contrast to CRP in the IDA group, had a significant divergence (p <0.05). Hepcidin was higher in women with IDA without OB (p<0.05) versus women with OB and controls, both of which did not significantly differ (p> 0.05).

CONCLUSIONS: The level of systemic inflammation in women with iron deficiency anemia with obesity is less than in women with obesity without this anemi, as shown by serum levels of IL-6 and CRP. Iron deficiency anemia may protect obese women from some aspects of systemic inflammation.