731:
Sensitization to House Dust Mites in Patients with Irritable Bowel Syndrome
Monday, March 5, 2018
South Hall A2 (Convention Center)
Anastasia Levchenko, Liliia Romaniuk, MD PhD, Ilona DuBuske, Lawrence Dubuske
RATIONALE: House dust mites (HDM) may enter the digestive tract in significant quantities, inducing allergic inflammation of gastrointestinal mucosa.

METHODS: The incidence of sensitization to HDM in Irritable Bowel Syndrome versus healthy individuals was assessed in 90 patients with IBS diagnosed based on the Roman criteria 4 and 60 healthy subjects of comparable gender and age. All patients responded to an initial questionnaire survey and a detailed allergy medical history. An enzyme-linked immunoassay for specific IgE in serum was done for D.Pteronisimus and D.farinae.

RESULTS: 58 patients with IBS (64.44%) and 18 patients (30%) in the control group (p<0.01) had moderate and high level of sensitization to D.pteronisimus and 42 patients with IBS (46.6%) and 17 (28.3%) patients in the control group had similar sensitization to D. Farinae . Simultaneous sensitization to both mites was detected in 35 patients with IBS (38.8%) and only in 6 (10%) patients in the control group (p <0.005). Very high sensitization to these allergens was detected in 2 patients with IBS and none in the control group.

CONCLUSIONS: Sensitization to HDM occurs in patients with IBS significantly more often than in healthy people. HDM is a possible new environmental trigger that contributes to the pathogenic mechanism of IBS in susceptible patients.