METHODS: Clinical and sociodemographic data of patients diagnosed with CU and ASST performed in our hospital between 2009 and 2014, were reviewed. Age, gender, refractoriety to treatment, disease duration, development of thyroiditis and other autoimmune diseases were analyzed and compared between the positive (ASST+) and negative (ASST-) ASST groups.
RESULTS: 71 patients, 50 females and 21 males, with an average age of 52.8 years were selected. There were no significant differences in age and sex between the groups. In the ASST+ group, 45% of CU were refractory to the standard treatment (double dose of antihistamines) and 81% of CU were persistent after 3-5 years vs. 6% and 21% in the ASST- group, respectively. After five years, 25% of ASST+ patients were diagnosed with an autoimmune disease and 25% of these had autoimmune thyroiditis vs. 8.5% and 14%, respectively, for ASST- patients. Helicobacter Pylori was detected in 60% of ASST+ patients vs. 4.7% of ASST- patients.
CONCLUSIONS: ASST could represent a useful and cheap tool as a prognostic factor for the duration and severity of CU in clinical practice, although further investigation is needed.