Impact of Laser Therapy on Immune Responses in Acne Patients

RATIONALE: Acne may be associated with immune dysfunction which ow-intensity (with capacity of 1-20 mV) laser therapy may impact due to anti-inflammatory, antibacterial or bacteriostatic action.

METHODS: 72 patients (aged 18-25) with acne were assessed including 29 (40.28 %) with mild acne, 30 (41.76%) with moderate acne, and 13 (18.06 %) with severe acne. 26 healthy person of similar age served as controls. Systemic immunity indicators were assessed. Patients were divided into two groups:1) received standard therapy with immunotropic medication; and 2) the second (main) - secondary to the standard therapy with immunotropic medication and combined laser therapy with percutaneous laser irradiation of blood and differentiated external laser therapy.

RESULTS: Group 1 had increase of CD3+ by 15.3%, (p<0.001), increase of CD4+ by 20.7%, (p<0.001), increase of CD8+ by 9.1%, (p<0.05), and decrease of CD19+ by 16.4%, (p<0.01). Group 2 had even greater positive changes in immune status with increase of CD3+ by 25.0% (p<0.001), increase of CD4+ by 35.5% (p<0.001), increase of CD8+ by 19.8%, (p<0.001) and decrease of CD19+ by 19.4% (p<0.001).

CONCLUSIONS: Immunotropic medication combined with laser therapy improved systemic immune responses in patients with acne.