432:
Patch Testing in Patients with Atopy
Sunday, March 4, 2018
South Hall A2 (Convention Center)
Irum Noor, DO, Marcella R. Aquino, MD FAAAAI, Mark A. Davis-Lorton, MD FAAAAI, Luz S. Fonacier, MD FAAAAI
RATIONALE:

Newer data demonstrates that contact sensitization is at least as common in atopic dermatitis (AD) patients as it is in the general population which is contrary to previous beliefs. We sought to compare positive patch test (PPT) results in patients with atopy and AD (AT w/AD) and atopy without AD (AT w/o AD) to our control group, those without atopy (w/oAT). We hypothesized that impaired skin barrier function which increases allergen penetrance in atopic patients with AD increases risk of sensitization.

METHODS:

An IRB-approved retrospective 7 year chart review was performed of 114 patients patch tested with the North American Contact Dermatitis Group Standard (NACDG) or the Thin-Layer Rapid Use Epicutaneous (T.R.U.E.) test at our allergy practice. Data collected included atopic disease type (food allergy, allergic rhinitis, asthma, & AD), location of dermatitis, occupation, and rate of PPT to at least 1 allergen.

RESULTS:

The age range was 13 – 95 years and 83% were female. Nineteen percent (n-22) had allergic rhinitis (AR), asthma, and/or food allergy (FA) with AD, 47% (n=53) had AR, asthma, and/or FA without AD and 34% (n=39) had no atopy. In the AT w/ AD group, 82% of patients had a PPT. Patients in the AT w/o AD and the w/oAT had similar rates of at least 1 PPT (53% and 64% respectively; p-value = 0.06).

CONCLUSIONS:

In our patient population, AT w/AD had a higher likelihood of sensitization to contact allergens compared to AT w/oAD and w/o AT. Larger studies in these populations are warranted for confirmation.